Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. Similar to your teeth, your arteries form many layers of plaque that can be difficult to remove. Nonenveloped viruses often lyse infected cells, set free progeny and spread to neighboring. Atherosclerosis and its clinical sequelae represent a huge and increasing global burden of morbidity and mortality in the form of coronary artery, peripheral vascular and cerebral vascular disease. As lipids, macrophages and smooth muscle continue to accumulate the plaque grows in size and matures. Stenting and surgery for narrow carotid arteries, both minimally invasive procedures, are equally effective, the 10year study has concluded. Atherosclerosis is the pathologic process by which cholesterol and calcium plaque accumulate within the arterial wall.
Smartdraw includes s of professional healthcare and anatomy chart templates that you can modify and make your own. The causal link between iron and atherosclerosis has been debated. Full text is available as a scanned copy of the original print version. Ppt atherosclerosis powerpoint presentation free to view. Pathogenesis of plaque formation the herald lesion in the arteries is endothelial dysfunction triggered by exposure of the endothelium to one or more of the following agents. Effect of mouthwash with boswellia extract on the prevention of dental plaque formation in patients under mechanical ventilation.
Atherosclerosis is a major cause of death worldwide and is the underlying cause of cardiovascular diseases, such as heart attack and stroke 1 3. Free powerpoint templates download free powerpoint backgrounds and powerpoint slides on atherosclerosis anatomy powerpoint template this template has a nice skeleton image in the presentation background and it is very useful for presentations on anatomy and osteoporosis. Atherosclerosis is a multifocal, smoldering, immunoinflammatory disease of mediumsized and large arteries fuelled by lipids. It is characterized by the formation of fattyfibrous plaques at specific arterial sites through a decadeslong process driven by lipoprotein deposition in the vessel wall. Find out more about atherosclerosis causes, symptoms, risk.
At the core of this condition is the atherosclerotic plaque. After decades of indolent progression, such plaques may suddenly cause lifethreatening coronary thrombosis presenting as an acute coronary syndrome. If you want to download this powerpoint template, yes, no b. Atherosclerosis is a disease in which the inside of an artery narrows due to the build up of plaque. Lipidloaded foam cells have traditionally been regarded as derived from. Inflammation plays a major role for the formation of plaque and subsequent plaque rupture, which finally leads to heart attack. The most devastating consequences of atherosclerosis, such as heart attack and stroke, are caused. Progression of atherosclerosis in apoeknockout mice fed. In a recent paper hao and friedman in plos one e90497, 2014, we have developed a mathematical model of plaque growth. Vincent calvez 1, abderrhaman ebde 2, nicolas meunier 3 and annie raoult 3 abstract. The classical atherosclerotic lesion is an inflammatory fibrofatty plaque. A consensus statement from the european atherosclerosis society consensus panel.
Pathogenesis of atherosclerosis hematology american. Atherosclerotic plaque vulnerability in the statin era. The intercellular networking that occurs among smooth muscle cells, macrophages, t lymphocytes and endothelial cells leads to a fibroproliferative response, in which the extracellular matrix ecm plays an important role. Coronary artery disease coronary artery disease is one of the most common and serious effects of aging.
Endothelial function and inflammation in coronary artery. Nodular smooth muscle cells hyperplasia with elastic tissue proliferation and subsequent fibrotic transformation are the early intimal changes of the plaque formation. B, diagram of fatty streak and lipid core formation. Some of the most valuable information on supragingival biofilm formation, ecology.
Mk may serve as a potential therapeutic target for the prevention of atherosclerosis under atherogenic conditions. Atherosclerosis atherosclerosis vessels of the heart atherosclerosis medical vector illustration cross section diagram, unhealthy blood vessel circulatory system disease. Spatial localisation of oxidative and inflammatory markers. A free powerpoint ppt presentation displayed as a flash slide show on id. Once atherosclerotic plaques begin to protrude into the lumen they will disturb laminar blood flow causing changes in shear stress similar to those observed at bifurcations. Clinical studies have shown their prognostic potential for the development of ischaemic events and for adverse outcome after acute coronary syndromes.
Computational modeling of atherosclerosis pdf free download. How atherosclerosis plaque forms watch webmd video. Atherosclerosis refers to the buildup of fats, cholesterol and other substances in and on your artery walls plaques, which can restrict blood flow. Atherosclerosis is a specific type of arteriosclerosis, but the terms are sometimes used interchangeably. Development of atherosclerosis and plaque biology sciencedirect. Article information, pdf download for inhibition of plaque formation and gingivitis in. This condition is a process in which deposits of fatty material, called plaque, build up inside the walls of arteries, reducing or completely blocking blood flow. When severe, it can result in coronary artery disease, stroke, peripheral artery disease, or kidney problems, depending on which arteries are affected. Mechanisms of plaque formation and rupture circulation research. Atherosclerosis is a lipoproteindriven disease that leads to plaque. Finnaly artery lumen is narrowed and lead to thrombosis and arterial occlusion.
Overall, these data demonstrate that dental plaque edna is. Biomarkers for diagnosis of the vulnerable atherosclerotic plaque. Atherosclerosis coronary heart disease and the recent advancements in the treatment of atherosclerosis. Atherosclerosis, the leading cause of death in the us, is a disease in which a plaque builds up inside the arteries.
Arteriosclerosis from the greek arteria, meaning artery is a general term for hardening of the arteries. Growth of necrotic cores in atherosclerotic plaque. Atherosclerotic plaque an overview sciencedirect topics. Endothelial cells ecs exhibit highly active glycolysis, the dysfunction of which leads to accumulation of lipids in the arterial wall and formation of atherosclerotic plaque. Atherosclerotic plaque formation is fueled by the persistence of lipidladen macrophages in the artery wall. Atherosclerotic plaque rupture and thrombus formation are key events resulting in ischemic stroke as well as myocardial infarction. Midkine promotes atherosclerotic plaque formation through. D antibodies plus protein l 7, with plaque formation being visualised. Liu progression of atherosclerosis in apoeknockout mice fed on a highfat diet. Atherosclerotic plaque formation is greatest at the branching points of major vessels and forms in areas of turbulent flow. The present thinking on this theory views atherosclerosis as a stereotype. Atherosclerosis is recognized as a chronic inflammatory disease leading to hardening of the vessel wall and narrowing of arteries. Because heart disease is the leading cause of death in this country, and millions of people are affected by it every day, its likely that you know someone who has had a.
Stable plaque formation buy this stock vector and explore similar vectors at adobe stock. Role of the pst system in plaque formation by the intracellular pathogen shigella flexneri. Atherosclerosis is primarily a lesion that progresses due to a series of reactions that are induced by repair of injured intima. Lowdensity lipoproteins cause atherosclerotic cardiovascular. Plaque is made up of fat, cholesterol, calcium, and. In human pathology the formation, progression and significance of the atherosclerotic plaque are still matter of investigation.
Chapter 1 computational modeling of atherosclerosis contents 1 theoretical background 2 methods 2. Recent studies have revisited the iron hypothesis by showing that dietary iron overload or elevated nontransferrin bound iron ntbi aggravates atherosclerosis in mice by driving vascular dysfunction, thus identifying ntbi as a risk factor and therapeutic target for atherosclerosis. Inflammation in atherosclerotic plaque formation youtube. Atherosclerotic plaque composition and occurrence of. Landmark study clarifies stroke prevention options.
Evidence from genetic, epidemiologic, and clinical studies. Atherosclerosis is a lipoproteindriven disease that leads to plaque formation at specific sites of the arterial tree through intimal inflammation, necrosis, fibrosis, and calcification. Pathological findings derived from humans and animal models of human. Original article rosuvastatin attenuates the progression of atherosclerotic plaque formation in apoemice xiuwen du 1, cai gao, youwei han 2, xiaoxia liu2, lin wang, hongju jiang2 1shandong university of traditional chinese medicine, jinan, shandong, china. Here, we investigated whether large dose of ang17 and losartan are equivalent or the combination of both is superior in reducing atherosclerotic plaque formation. Atherosclerosis, more commonly known as heart disease, is a serious and lifethreatening condition. This insidious process renders plaque accumulation in.
Atherosclerosis detailed illustration, progression till thrombus, blood clot, unstable plaque formation in the artery. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. Atherosclerosis anime icon vector fat stuck in the blood artery cholesterol atherosclerosis atherosclerosis atherosclerosis severe atherosclerosis banner. Process of atherosclerosis plaque formation animation. Ppt atherosclerosis powerpoint presentation free to. Objective to investigate the relationship between atherosclerotic plaque histology and the occurrence of restenosis after carotid endarterectomy.
Article information, pdf download for a critical role for extracellular dna in. Atherosclerosis is the build up of a waxy plaque on the inside of blood vessels. A plaque buildup in your ateries can spell trouble. Role of the pst system in plaque formation by the intracellular. Arteriolosclerosis small arteries and arterioles hypertension and dm. Atherosclerosis or hardening of the arteries is the leading cause of heart attacks, strokes, and peripheral vascular disease. The mechanisms by which these cells become trapped, thereby establishing chronic inflammation, remain unknown.
Atherosclerosis is the most common arterial abnormality characterized as arteriosclerosis, which is. Savoir realiser les cloisons et les plafonds en plaques. Via these consecutive steps, an atherosclerotic plaque is formed. Plaque burden denotes the extent of disease, whereas plaque activity is an ambiguous term, which may refer to one of several processes that characterize progression. Lipoproteins as biomarkers and therapeutic targets in the setting of acute coronary syndrome. Arteries are blood vessels that carry oxygenrich blood to your heart and other parts of your body. Chronic hypertension is a common precursor, and damage to the intimal wall may be followed by lymphocyte infiltration. Subgingival biofilms in periodontal pockets are not easily analyzed without the loss of structural integrity. Follow exactly how atherosclerosis blocks blood flow. A critical role for extracellular dna in dental plaque formation n. Atherosclerotic plaque definition of atherosclerotic plaque. The maturation process is best exemplified by the formation of the fibrouscap composed mainly of smooth muscle cells that interposes itself between the inner core of the plaque and the vascular lumen. Endothelial cells, leukocytes, and intimal smooth muscle cells are the major players in the development of this disease.
This article is devoted to the construction of a mathematical model describing the early formation of atherosclerotic lesions. However, direct comparison of ang17 and angiotensin ii type 1 receptor blocker arb on atherogenesis is sparse. Inflammation and its resolution as determinants of acute coronary syndromes. Comprehensive intravascular imaging of atherosclerotic. Atherosclerosis free medical powerpoint background free. Inhibition of plaque formation and gingivitis in beagle dogs by. Mathematical modelling of the atherosclerotic plaque formation. The term athero means porridge and sclerosis means scarring. Mathematical modelling of atheroma plaque formation and. Dental plaque as a biofilm and a microbial community implications. There they can then be oxidized by free radicals to form a family. Lecture 30 pathology of atherosclerosis free download as powerpoint presentation. Imaging plaques to predict and better manage patients with acute coronary events.
Innate immune effectors, in particular monocytes and macrophages, play a pivotal role in atherosclerosis initiation and progression. Atherosclerosis european heart journal oxford academic. Factors contributing to the formation of vulnerable plaques. Symptoms, if they occur, generally do not begin until middle age. Atherosclerosiscoronary heart disease and the recent. Atherosclerosis is the most common arterial abnormality characterized as arteriosclerosis, which is defined by.
Atherosclerotic plaque characterization methods based on. Atherosclerosis powerpoint template free download free. Atherosclerosis gives rise to cerebrovascular disease and cad through a slowly progressing lesion formation. Plaque vulnerability describes the shortterm risk of precipitating symptomatic thrombosis. Biomarkers for diagnosis of the vulnerable atherosclerotic. Lipid retention is the first step in the pathogenesis of atherosclerosis which is followed by chronic inflammation at.
Cell biology, geometrical, microanatomical, mechanical hemodynamical and microenvironmental factors have been extensively studied and contribute to our present knowledge on tissue processes associated with vascular adaptation to plaque formation and plaque stability. Nonlinear dynamics of early atherosclerotic plaque formation may. Reduction in inflammatory levels and improving endothelial function by traditional and novel treatment strategies were. Foam cell formation due to cholesterol overloading is the defining pathologic characteristic of atherosclerotic plaques. Probiotic administration of lactobacillus rhamnosus gr1 attenuates atherosclerotic plaque formation in. The formation of the plaque can also be divided into three major stages namely 1 the fatty streak, which represents the initiation 2 plaque progression, which represents adaption and 3 plaque disruption, which represents the clinical complication of atherosclerosis. A process similar to bone formation causes calcification within the plaque. Plaque rupture in coronary atherosclerosis is associated. Evidence supports the central role of endothelium and inflammation in all phases of the atherosclerotic process.
Atherosclerosis, chronic disease caused by the deposition of fats, cholesterol, calcium, and other substances in the innermost layer of endothelium of the large and mediumsized arteries. However, prospective intravascular ultrasoundvirtual histology studies indicate that plaques cause clinical events over 3 years, indicating that other factors also determine plaque rupture. Scap knockdown in vascular smooth muscle cells alleviates. Atherosclerosis begins with fatty streak which is a accumulation of lipid laden foam cells in the intimal layer of the artery 4. Atherosclerotic plaque formation is the result of inflammatory processes that mediate lymphocyte and macrophage infiltration, lipid intra and intercellular deposition and eventually smooth. The authors, with their expertise from biomedical engineering, computer science, and cardiology, offer a holistic view.
The composition of the atherosclerotic plaque at the intervention site has not been evaluated as a marker for restenosis. In greek, athere means gruel, and skleros means hard. The result is a subendothelial fibrous plaque with a fibrous cap, made of intimal smooth muscle cells surrounded by connective tissue and intracellular and extracellular lipids. Proposed biomarkers for the study of initiation, progression and destabilization of the atherosclerotic plaque. Mathematical modelling of the atherosclerotic plaque formation vincent calvez. Fatty deposits build up in blood vessel walls and narrow the. A mathematical model of atherosclerosis with reverse. It is within the structure of this lesion that multiple biochemical and cellular processes interact. Cholesterol crystals are within the plaque also derived from circulating lipoproteins. Lowdensity lipoproteins cause atherosclerotic cardiovascular disease. Background plaque rupture is the most common cause of myocardial infarction, occurring particularly in higher risk lesions such as fibroatheromas.
Article information, pdf download for inhibition of plaque formation and. Early notions of atherosclerosis were based on progressive calcification, however, atherosclerosis is now appreciated to be. A selfdisintegrating filmforming solution was applied. Once youve been diagnosed with the disease, youll need to make very important, lasting. Arteriosclerosis can occur in several forms, including. The low density lipoprotein ldl and high density lipoprotein hdl concentrations in the blood are commonly used to predict the risk factor for plaque growth. Atherosclerosis stock photography images royalty free at. Atherosclerosis is one of the leading causes of death and disability worldwide. In the us alone, cad affects 16 million adults, accounts for of all deaths, and is responsible for 1. Development and application of a simple plaque assay for. Feb 11, 2015 atherosclerosis is when harmful material collects on the wall of an artery. Atherosclerotic plaques definition of atherosclerotic. Macrophages join to each the fat foamy cells and t lymphocytes to provide cytokines to promote the process.
This medical powerpoint template does not have any watermarks or names on it, so feel free to use it however you want. Oxidative and inflammatory markers within advanced atherosclerotic plaques a thesis submitted in partial fulfilment of the requirements for the degree of master of science in biochemistry at the school of biological sciences university of canterbury new zealand elizabeth m. But they may become vulnerable, there is a risk of rupture and lead to thrombosis. Original article rosuvastatin attenuates the progression. Coronary artery disease cad is the principal cause of morbidity and mortality worldwide. Inflammation in atherosclerotic plaque formation youtube docteur imane. Stable atherosclerotic plaque formation in the human artery, they tend to be asymptomatic. Mechanisms of plaque formation and rupture circulation. Atherosclerotic plaque vulnerability in the statin era jan nilsson. It is a complex disease characterized by lipid accumulation within the arterial wall, inflammation, local neoangiogenesis, and apoptosis. Atherosclerosis is a common disease that occurs when the inside of arteries have plaque buildup.